My 14 year old daughter, her mom and stepdad, just moved back to SC from Asheville, this past Tuesday, after living 3 years in a loft apartment next door to the Mast General Store on Biltmore Ave . They are living temporarily in an apartment complex in Greenville, called McBee Station, while the town home they have under contract on the other side of downtown is constructed. I live in Columbia, which has been considerably less conservative than the upstate during my lifetime. However, I've worked in Greenville for 20 plus years, and took trips there to visit family, and I can, without reservation tell you, Greenville (the city..can't speak for the county) is a fantastic, arts friendly, people friendly, business friendly place, set in a photogenic spot just shy of the mountains. I think you too will love it, as I hope my daughter loves it. It is only 1 hour and 45 min from my house, so a much better drive than Asheville. Its downtown is very clean, and orderly, and the Peace Center is always putting out diverse and impressive offerings. I'd say go for it. Check out Columbia and Charleston, too. All very different places, but all score high on quality of life, in my mind's eye.