My understanding is that the House of Louie is being demolished since they have relocated to near where I live in the Freedom Florence area. I have no way to confirm this, but I believe Walgreens is building on their former site.
As for Ruby's place, she is in the county so city ordinances do not apply to her. She purchased that property when it was considered a rural area. This is her homestead and she will fight change. Remember, she is 83 years old. I am in her family, and change will come in due time.
I can't speak on the other properties mentioned, but I agree with most of your comments, especially if it is abandoned property. As for the businesses mentioned, maybe they cannot afford to make their places more attractive. Maybe the county should offer some type of incentive to help them out.